In this lecture divided into 11 chapters, Dr Bushnell explains which brain regions are involved in pain processing and pain modulation; describes the effects of chronic pain on the brain and how psychologically based therapies influence these effects; discuss the differences in how emotional state and attentional focus alter pain; talks about the CAM (Complementary and Alternative Medicine) as hypnosis, acupuncture, yoga, meditation, neurostimulation and placebo effects for mind-body pain therapy.